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LEP(116-130)(mouse)

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Purity:100%

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COA LCMS

LEP(116-130)(mouse)

Catalog No. TP1305Cas No. 258276-95-8

Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis.

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Pack Size	Price	Availability
1 mg	$85	In Stock
2 mg	$133	In Stock
5 mg	$259	In Stock
10 mg	$426	In Stock
25 mg	$691	In Stock
50 mg	$963	In Stock
100 mg	$1,280	In Stock

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Product Introduction

Bioactivity

Description	Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis.
In vitro	LEP-(116-130) (300 µM) is unable to inhibit AP-OB binding. Moreover, LEP-(116-130) was unable to activate signal transduction by OB-Rb in vitro[1].
In vivo	LEP-(116-130) (1 mg, i.p.) administration leads to a decrease in body weight gain despite elevated food consumption compared to vehicle-injected control mice. It also significantly lowers blood glucose levels by approximately 100 mg/dL. However, when administered to wild-type (+/+) C57BLKS/J-m mice for either 4 or 7 days, LEP-(116-130) does not impact their thermoregulatory capabilities[1].

Chemical Properties

Molecular Weight	1560.73
Formula	C64H109N19O24S
Cas No.	258276-95-8

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10mM

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6407 mL	3.2036 mL	6.4073 mL	32.0363 mL
5 mM	0.1281 mL	0.6407 mL	1.2815 mL	6.4073 mL

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Keywords

LEP(116-130)(mouse)InhibitorLEP(116130)(mouse)LEPinhibitLEP(116 130)(mouse)