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Leteprinim

🥰Excellent
Catalog No. T32658LCas No. 138117-50-7
Alias AIT-082 acid, AIT082 acid, AIT 082 acid

Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.

Leteprinim

Leteprinim

🥰Excellent
Purity: 98.93%
Catalog No. T32658LAlias AIT-082 acid, AIT082 acid, AIT 082 acidCas No. 138117-50-7
Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.
Pack SizePriceAvailabilityQuantity
1 mg84 €In Stock
2 mg119 €In Stock
5 mg187 €In Stock
10 mg283 €In Stock
25 mg452 €In Stock
50 mg644 €In Stock
100 mg866 €In Stock
200 mg1.159 €In Stock
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Purity:98.93%
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Product Introduction

Bioactivity
Description
Leteprinim (AIT 082 acid) is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.
In vitro
Leteprinim stimulates the outgrowth of neurites from PC12 cells and neurons, stimulates the synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo, and enhances memory in animals and humans. Leteprinim also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of Leteprinim in animal models of acute central nervous system injury[3].
In vivo
Leteprinim (60 mg/kg/day; i.p., for 7 days, starting from 20 min before the kainate injection) did not modify the seizures caused by kainate but, like diazepam, it decreased kainate-induced mortality, the reduction of GAD activity, and the loss of hippocampal neurons in rats[2].
AliasAIT-082 acid, AIT082 acid, AIT 082 acid
Chemical Properties
Molecular Weight327.29
FormulaC15H13N5O4
Cas No.138117-50-7
SmilesC(CC(NC1=CC=C(C(O)=O)C=C1)=O)N2C3=C(C(=O)N=CN3)N=C2
Relative Density.1.57 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 12.5 mg/mL (38.19 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0554 mL15.2770 mL30.5539 mL152.7697 mL
5 mM0.6111 mL3.0554 mL6.1108 mL30.5539 mL
10 mM0.3055 mL1.5277 mL3.0554 mL15.2770 mL
20 mM0.1528 mL0.7638 mL1.5277 mL7.6385 mL

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