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LG100754

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LG100754

Catalog No. T15748Cas No. 180713-37-5

LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.

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Pack Size	Price	Availability
25 mg	$993	6-8 weeks
50 mg	$1,290	6-8 weeks
100 mg	$1,970	6-8 weeks

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Product Introduction

Bioactivity

Description	LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.
In vitro	LG100754 functions as an activator of endogenous RXR heterodimers, specifically facilitating the activity of RXR: PPARγ heterodimers. It plays a crucial role in regulating insulin-dependent signaling pathways. Additionally, LG100754 has been shown to mitigate TNFα-mediated insulin resistance in mature adipocytes[1].
In vivo	LG100754 (100 mg/kg) fully blocks the enhance in glucose levels. It also shows that LG100754 can improve insulin resistance in vivo[1].
Alias	UVI 2112

Chemical Properties

Molecular Weight	396.56
Formula	C26H36O3
Cas No.	180713-37-5

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (227.0 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5217 mL	12.6084 mL	25.2169 mL	126.0843 mL
5 mM	0.5043 mL	2.5217 mL	5.0434 mL	25.2169 mL
10 mM	0.2522 mL	1.2608 mL	2.5217 mL	12.6084 mL
20 mM	0.1261 mL	0.6304 mL	1.2608 mL	6.3042 mL
50 mM	0.0504 mL	0.2522 mL	0.5043 mL	2.5217 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2608 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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