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LG100754
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Catalog No. T15748Cas No. 180713-37-5
Alias UVI 2112
LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.
LG100754
😃Good
Catalog No. T15748Alias UVI 2112Cas No. 180713-37-5
LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $993 | 6-8 weeks | |
| 50 mg | $1,290 | 6-8 weeks | |
| 100 mg | $1,970 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers. |
| In vitro | LG100754 functions as an activator of endogenous RXR heterodimers, specifically facilitating the activity of RXR: PPARγ heterodimers. It plays a crucial role in regulating insulin-dependent signaling pathways. Additionally, LG100754 has been shown to mitigate TNFα-mediated insulin resistance in mature adipocytes[1]. |
| In vivo | LG100754 (100 mg/kg) fully blocks the enhance in glucose levels. It also shows that LG100754 can improve insulin resistance in vivo[1]. |
| Alias | UVI 2112 |
| Molecular Weight | 396.56 |
| Formula | C26H36O3 |
| Cas No. | 180713-37-5 |
| Smiles | CCCOc1cc2c(cc1\C(C)=C/C=C/C(/C)=C/C(O)=O)C(C)(C)CCC2(C)C |
| Relative Density. | 1.003g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (227.0 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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