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LGD-2226
LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle wasting, osteoporosis, and sexual dysfunction.
Catalog No. T15749Cas No. 328947-93-9
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LGD-2226
Catalog No. T15749Cas No. 328947-93-9
LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle wasting, osteoporosis, and sexual dysfunction.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle wasting, osteoporosis, and sexual dysfunction. |
| Targets&IC50 | Androgen receptor:(EC50)0.2 nM, Androgen receptor:(ki)1.5 nM |
| In vitro | LGD-2226 occupies the same binding pocket as dihydrotestosterone (DHT), the protein backbone is superposable to that observed with DHT. The trifluoroethyl groups of LGD-2226 occupy the same space in the receptor as the C and D rings of the steroid. GLN711 forms an additional hydrogen bond with the quinolone NH of LGD-2226. Just like the carbonyl group of DHT, the quinolone carbonyl forms hydrogen bond interactions with GLN711 and ARG752 [1]. |
| In vivo | LGD-2226 has weak trophic effects on the prostate. LGD-2226 (100 mg/kg) treatment, is required to maintain prostate weight at intact levels. LGD-2226 (1-100 mg/kg; p.o.; daily; for 2 weeks; adult oORDX rats) has a pronounced effect on the levator ani muscle, maintaining the muscle weight at the eugonadal levels at an approximate 3 mg/kg dose. These data clearly show the tissue selectivity of LGD-2226[1]. |
| Molecular Weight | 392.22 |
| Formula | C14H9F9N2O |
| Cas No. | 328947-93-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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