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Licarin A
🥰Excellent
Catalog No. T20728Cas No. 51020-86-1
Alias (-)-Licarin A
Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression.
Licarin A
🥰Excellent
Catalog No. T20728Alias (-)-Licarin ACas No. 51020-86-1
Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 5 mg | $200 | In Stock | |
| 10 mg | $295 | In Stock | |
| 25 mg | $497 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Licarin A is a natural anti-inflammatory lignan that inhibiting PKCα/βII and p38 MAPK pathways, thereby decreasing TNF-α and prostaglandin D2 (PGD2) secretion as well as COX-2 expression. |
| In vitro | Methods: DNP-HSA-stimulated RBL-2H3 cells were treated with Licarin A (0-20 μM) to study the antiallergic effect on antigen-stimulated rat mast cell line. Results: The level of PGD2 secretion in DNP-HSA-stimulated cells pretreated with Licarin A was lower than that in cells stimulated with DNP-HSA alone (positive control); 20 μM Licarin A treatment produced a slight inhibition of DNP-HSA-induced increase in COX-2 mRNA and protein levels; Licarin A reduced TNF-α and PGD2 secretion by inhibiting PKCα/βII and p38 MAPK pathways; this compound may be useful in alleviating immediate hypersensitivity reactions. [5] |
| Alias | (-)-Licarin A |
| Molecular Weight | 326.39 |
| Formula | C20H22O4 |
| Cas No. | 51020-86-1 |
| Smiles | O(C)C1=C2C([C@@H](C)[C@@H](O2)C3=CC(OC)=C(O)C=C3)=CC(/C=C/C)=C1 |
| Relative Density. | 1.16g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (122.55 mM), Sonication is recommended. H2O: < 0.1(insoluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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