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Product Introduction

Bioactivity

Description	Methyl 3-O-methylgallate (M3OMG) is a rare natural product with promising antioxidant activities.
In vitro	Methyl 3-O-methylgallate showed antioxidant activity without prooxidant effect in neuronal SH-SY5Y cells[2].
In vivo	Animals were treated with either Methyl 3-O-methylgallate(10 and 20 mg/kg i.p.), vitamin C (10 mg/kg i.p.) as the standard antioxidant or the vehicle (5 % dimethyl sulfoxide; 1 ml/kg) for 1 week. Oxidative stress was induced in the brain by adding 600 ppm NaF in the drinking water for 7 days. At the end of the treatment period, the levels of thiobarbituric acid reactive substances (TBARS), reduced glutathione and the activities of antioxidant enzymes (superoxide dismutase and catalase) were evaluated in brain homogenates. Methyl 3-O-methylgallate mitigated the NaF-induced oxidative stress through normalization of the level of TBARS, reduced levels of glutathione and by the restoration of the diminished antioxidant enzyme activities[1].
Alias	M3OMG

Chemical Properties

Molecular Weight	198.17
Formula	C₉H₁₀O₅
Cas No.	3934-86-9
Smiles	COC(=O)c1cc(O)c(O)c(OC)c1
Relative Density.	1.337g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (252.31 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0462 mL	25.2309 mL	50.4617 mL	252.3086 mL
5 mM	1.0092 mL	5.0462 mL	10.0923 mL	50.4617 mL
10 mM	0.5046 mL	2.5231 mL	5.0462 mL	25.2309 mL
20 mM	0.2523 mL	1.2615 mL	2.5231 mL	12.6154 mL
50 mM	0.1009 mL	0.5046 mL	1.0092 mL	5.0462 mL
100 mM	0.0505 mL	0.2523 mL	0.5046 mL	2.5231 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Methyl 3-O-methylgallateMethyl 3OmethylgallateMethyl 3 O methylgallateInhibitorinhibit