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MitoBloCK-10

🥰Excellent
Catalog No. T8741Cas No. 394694-98-5
Alias 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m

MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.

MitoBloCK-10

MitoBloCK-10

🥰Excellent
Purity: 99.51%
Catalog No. T8741Alias 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)mCas No. 394694-98-5
MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
Pack SizePriceAvailabilityQuantity
1 mg$64In Stock
5 mg$155In Stock
10 mg$228In Stock
25 mg$388In Stock
50 mg$568In Stock
100 mg$812In Stock
1 mL x 10 mM (in DMSO)$146In Stock
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Purity:99.51%
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Product Introduction

Bioactivity
Description
MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
Alias3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m
Chemical Properties
Molecular Weight293.27
FormulaC12H8FN3O3S
Cas No.394694-98-5
Smiles[O-][N+](=O)c1ccc(\C=N\NC(=O)c2cccc(F)c2)s1
Relative Density.1.47 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (34.1 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4098 mL17.0491 mL34.0983 mL170.4914 mL
5 mM0.6820 mL3.4098 mL6.8197 mL34.0983 mL
10 mM0.3410 mL1.7049 mL3.4098 mL17.0491 mL
20 mM0.1705 mL0.8525 mL1.7049 mL8.5246 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

MitochondrialProteinTim44MitoBloCK10MitoBloCK-103-fluoro-N'-[(5-nitrothiophen-2-yl)mMitoBloCK 10inhibitInhibitorImport
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