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MKI-1
🥰Excellent
Catalog No. T60688Cas No. 1190277-80-5
Alias MASTL Kinase Inhibitor-1
MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer.
MKI-1
🥰Excellent
Purity: 99.50%
Catalog No. T60688Alias MASTL Kinase Inhibitor-1Cas No. 1190277-80-5
MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $80 | In Stock | |
| 5 mg | $197 | In Stock | |
| 10 mg | $318 | In Stock | |
| 25 mg | $538 | In Stock | |
| 50 mg | $872 | In Stock | |
| 100 mg | $1,330 | In Stock | |
| 500 mg | $2,660 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $217 | In Stock |
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Purity:99.50%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer. |
| Targets&IC50 | MASTL:9.9 μM |
| In vitro | MKI-1 (20 μM, 16 h) reduces c-Myc stability through PP2A activation in MCF7 cells. MKI-1 (5-20 μM) inhibits the activity of MASTL in breast cancer cells. MKI-1 (100 μM, 72 h) inhibits various oncogenic properties of breast cancer cells but showed much weaker effects on the viability of normal breast cells. MKI-1 clearly reduces both total c-Myc and serine 62-phosphorylation of c-Myc, with a decrease in ENSA phosphorylation[1]. |
| In vivo | MKI-1 (50 mg/kg, ip, twice a week) enhances the radiosensitivity of the BT549 xenograft model to 6 Gy irradiation, reducing tumor growth without significant changes in body weight [1]. |
| Alias | MASTL Kinase Inhibitor-1 |
| Molecular Weight | 302.33 |
| Formula | C18H14N4O |
| Cas No. | 1190277-80-5 |
| Smiles | O=C(Nc1nc2ccccc2[nH]1)c1cccc(c1)-n1cccc1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225.0 mg/mL (744.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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