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ML 145
🥰Excellent
Catalog No. T12074Cas No. 1164500-72-4
Alias ML145
ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.
ML 145
🥰Excellent
Catalog No. T12074Alias ML145Cas No. 1164500-72-4
ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $92 | In Stock | |
| 5 mg | $148 | In Stock | |
| 10 mg | $218 | In Stock | |
| 25 mg | $369 | In Stock | |
| 50 mg | $549 | In Stock | |
| 100 mg | $789 | In Stock | |
| 200 mg | $1,132 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis. |
| Targets&IC50 | CXCR8:20.1 nM, GPR35:21.7 μM |
| In vitro | ML 145 is a selective and competitive human antagonist of GPR35/CXCR8 with an IC50/EC50 value of 20.1 nM, compared to GPR35, which is over 1000-fold more selective than GPR55, which has an IC50/EC50 value of 21.7 μM. [1] In addition, ML 145 at 10 μM completely blocked the internalization of human FLAG-GPR35-eYFP in response to various concentrations of Zaprinast, Cromolyn disodium and Pamoate. In rodents, ML 145 was ineffective in mice and showed only a slight non-competitive inhibitory effect in rats. [2] |
| Alias | ML145 |
| Molecular Weight | 482.57 |
| Formula | C24H22N2O5S2 |
| Cas No. | 1164500-72-4 |
| Smiles | C(\C(=C\C1=CC=CC=C1)\C)=C\2/C(=O)N(CCCC(NC3=CC(O)=C(C(O)=O)C=C3)=O)C(=S)S2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (82.89 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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