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MS159
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Catalog No. T77967Cas No. 3031353-59-7
MS159 is a potent PROTAC degrader targeting the nuclear receptor binding SET structural domain protein 2 (NSD2), which inhibits tumor cell growth. This compound serves as a valuable chemical tool for investigating NSD2's function in health and disease [1].
MS159
😃Good
Catalog No. T77967Cas No. 3031353-59-7
MS159 is a potent PROTAC degrader targeting the nuclear receptor binding SET structural domain protein 2 (NSD2), which inhibits tumor cell growth. This compound serves as a valuable chemical tool for investigating NSD2's function in health and disease [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | MS159 is a potent PROTAC degrader targeting the nuclear receptor binding SET structural domain protein 2 (NSD2), which inhibits tumor cell growth. This compound serves as a valuable chemical tool for investigating NSD2's function in health and disease [1]. |
| In vitro | MS159, administered at concentrations ranging from 0.5 to 10 μM over 48 hours, triggers the time- and dose-dependent degradation of NSD2 protein in 293FT cells, which is a reversible process [1]. At a concentration of 2.5 μM and after 72 hours, MS159 not only induces NSD2 degradation, but also effectively degrades IKZF1 and IKZF3 in KMS11 and H929 multiple myeloma cell lines; this degradation is facilitated by the ubiquitin-proteasome system (UPS-) and cereblon (CRBN-) mechanisms [1]. Further, sustained treatment of MS159 (2.5 μM for 8 days) significantly hampers the growth of these multiple myeloma cells, which is attributed to the induced degradation of NSD2 [1]. |
| Molecular Weight | 828.83 |
| Formula | C43H40N8O10 |
| Cas No. | 3031353-59-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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