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MS15 TFA
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Catalog No. T77968
MS15 TFA is a potent, selective AKT PROTAC degrader, effectively inhibiting AKT1, AKT2, and AKT3 with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1].
MS15 TFA
MS15 TFA
😃Good
Catalog No. T77968
MS15 TFA is a potent, selective AKT PROTAC degrader, effectively inhibiting AKT1, AKT2, and AKT3 with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | MS15 TFA is a potent, selective AKT PROTAC degrader, effectively inhibiting AKT1, AKT2, and AKT3 with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1]. |
| In vitro | MS15 (0-10 μM, 24 hours) TFA effectively induces AKT degradation in SW620 cells and MS21 resistant cells harboring KRAS/BRAF mutations [1]. Furthermore, MS15 (0-10 μM, 5 days) TFA suppresses the proliferation of KRAS mutant SW620 cells [1]. In a time- and UPS-dependent manner, MS15 (1 μM, 1-24 hours) TFA mediates AKT degradation [1]. |
| In vivo | MS15, administered intraperitoneally at a dose of 75 mg/kg in a single injection, exhibits bioavailability [1] in mice. |
| Molecular Weight | 1228.47 |
| Formula | C66H80F3N11O7S |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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