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MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L (IC50 = 2 nM), a key epigenetic regulatory protein involved in the development of cancers such as hematologic malignancies, thus MU1656 was able to significantly inhibit the proliferation of cancer cells and induce apoptosis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $2,390 | In Stock | |
25 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L (IC50 = 2 nM), a key epigenetic regulatory protein involved in the development of cancers such as hematologic malignancies, thus MU1656 was able to significantly inhibit the proliferation of cancer cells and induce apoptosis. |
Targets&IC50 | DOT1L:2 nM |
In vitro | MU1656 is a carbocyclic C-nucleoside analog of the natural nucleoside derivative EPZ004777. It is more stable in vivo than EPZ5676 (pinometostat) itself and has significantly lower toxicity. [1] |
Alias | MU 1656 |
Molecular Weight | 559.75 |
Formula | C32H45N7O2 |
Cas No. | 2766698-38-6 |
Smiles | O[C@H]1[C@H](C=2N3C(=CC2)C(N)=NC=N3)C[C@H](CN(C(C)C)[C@H]4C[C@@H](CCC=5NC=6C(N5)=CC=C(C(C)(C)C)C6)C4)[C@H]1O |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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