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N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

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Purity:99.76%

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COA HNMR LCMS

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

Catalog No. T12156Cas No. 97627-24-2

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures.

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Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$163	In Stock
10 mg	$278	In Stock
25 mg	$551	In Stock
50 mg	$793	In Stock
100 mg	$1,090	In Stock
500 mg	$2,190	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock

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Product Introduction

Bioactivity

Description

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures.

In vivo

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea shows anticonvulsant activity at 30 mg/kg in the initial tests with no signs of ataxia until 300 mg/kg.?The activity seen with 30 mg/kg 37 is still present 4 h postdose.?Compound is effective against seizures induced by maximal electroshock but does not protect mice from clonic seizures produced by the convulsant pentylenetetrazol.?The overall pharmacological profile suggests that Compound would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures[1].

Chemical Properties

Molecular Weight	261.71
Formula	C13H12ClN3O
Cas No.	97627-24-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (458.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8210 mL	19.1051 mL	38.2102 mL	191.0512 mL
5 mM	0.7642 mL	3.8210 mL	7.6420 mL	38.2102 mL
10 mM	0.3821 mL	1.9105 mL	3.8210 mL	19.1051 mL
20 mM	0.1911 mL	0.9553 mL	1.9105 mL	9.5526 mL
50 mM	0.0764 mL	0.3821 mL	0.7642 mL	3.8210 mL
100 mM	0.0382 mL	0.1911 mL	0.3821 mL	1.9105 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N(2Chloro6methylphenyl)N'4pyridinylureainhibitN (2 Chloro 6 methylphenyl) N' 4 pyridinylureaN-(2-Chloro-6-methylphenyl)-N'-4-pyridinylureaInhibitor