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Nitro-PDS-Tubulysin M
Catalog No. T18504Cas No. 1941168-69-9
Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker.
Nitro-PDS-Tubulysin M
Catalog No. T18504Cas No. 1941168-69-9
Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker.
| Pack Size | Price | Availability | Quantity |
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| 100 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker. |
| In vitro | The chemical compound ADC2-2 (anti-CD22 10F4v3 LC K149C Nitro-PDS-Tubulysin M) exhibits specific cytotoxicity against WSU-DLCL2 human diffuse large B-cell lymphoma tumors, achieving a half-maximal inhibitory concentration (IC50) of 0.147 nM. Similarly, ADC2-1 (anti-Napi2b 10H1.11.4B LC K149C Nitro-PDS-Tubulysin M) demonstrates targeted toxicity in human ovarian cancer cell lines IGROV-1 and OVCAR-3x2.1, with IC50 values of 2.07 nM and 1.004 nM, respectively[1]. |
| Molecular Weight | 1106.4 |
| Formula | C54H73N8O11S3 |
| Cas No. | 1941168-69-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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