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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker. |
In vitro | The chemical compound ADC2-2 (anti-CD22 10F4v3 LC K149C Nitro-PDS-Tubulysin M) exhibits specific cytotoxicity against WSU-DLCL2 human diffuse large B-cell lymphoma tumors, achieving a half-maximal inhibitory concentration (IC50) of 0.147 nM. Similarly, ADC2-1 (anti-Napi2b 10H1.11.4B LC K149C Nitro-PDS-Tubulysin M) demonstrates targeted toxicity in human ovarian cancer cell lines IGROV-1 and OVCAR-3x2.1, with IC50 values of 2.07 nM and 1.004 nM, respectively[1]. |
Molecular Weight | 1106.4 |
Formula | C54H73N8O11S3 |
Cas No. | 1941168-69-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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