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Nomilin
Catalog No. T3672Cas No. 1063-77-0
Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
Nomilin
Catalog No. T3672Cas No. 1063-77-0
Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $64 | In Stock | |
| 25 mg | $129 | In Stock | |
| 50 mg | $188 | In Stock | |
| 100 mg | $283 | In Stock | |
| 500 mg | $688 | In Stock |
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Purity:99.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Nomilin is naturally occurring triterpenoids, have immunomodulatory activity. |
| In vitro | Administration of Nomilin significantly retarded endothelial cell proliferation, invasion, migration and tube formation. It also possesses anti-proliferative activity against the number of human cancer cell lines including leukemia (HL-60), ovary (SKOV-3), liver (Hep G2), cervix (HeLa), stomach (NCI-SNU-1), and breast (MCF-7)[2]. Nomilin significantly decreased TRAP-positive multinucleated cell numbers compared with the control and exhibited no cytotoxicity. It decreases bone resorption activity and downregulates osteoclast-specific genes, NFATc1 and TRAP mRNA levels. Furthermore, Nomilin suppressed MAPK signaling pathways. Thus, Nomilin has inhibitory effects on osteoclastic differentiation in vitro[3]. |
| In vivo | Nomilin is an effective inducer of gluthathione S-transferase activity in mice and to inhibit carcinogenesis in the hamster buccal pouch assay. Nomilin can shorten anaesthetic-induced sleeping time in mice, probably through a stimulant action on the central nervous system [1]. Nomilin significantly inhibited tumour-directed capillary formation. Serum proinflammatory cytokines such as IL-1β, IL-6, TNF-α and GM-CSF and also serum NO levels were significantly reduced by the treatment of nomilin. Administration of Nomilin significantly reduced the serum level of VEGF, a proangiogenic factor and increased the antiangiogenic factors TIMP-1 and IL-2 [2]. |
| Cell Research | Cell lines: HUVECs. Concentrations: 5 μg-500 μg/ml. Incubation Time: 48 h. Method:. HUVECs were seeded (5000 cells/well) in 96-well flat-bottomed titer plate and incubated for 24 h at 37 °C in 5% CO2 atmosphere. Different concentrations of Nomilin (5 μg-500 μg/ml) were added and incubated further for 48 h. Before 4 h completion of incubation, 20 μl MTT (5 mg/ml) was added. Percentage of dead cells was determined using an ELISA plate reader set to record absorbance at 570 nm. |
| Animal Research | Animal Models: Four to six week old male C57BL/6 mice. Formulation: light paraffin oil. Dosages: 6 mg/kg, I.P. |
| Molecular Weight | 514.56 |
| Formula | C28H34O9 |
| Cas No. | 1063-77-0 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: Insoluble Ethanol: Insoluble DMSO: 50 mg/mL (97.17 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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