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NPC 15199

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Catalog No. T8638Cas No. 35661-60-0
Alias FMOC-L-Leucine

NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.

NPC 15199

NPC 15199

🥰Excellent
Purity: 99.94%
Catalog No. T8638Alias FMOC-L-LeucineCas No. 35661-60-0
NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.
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500 mg$29 In Stock
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Purity:99.94%
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Product Introduction

Bioactivity
Description
NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.
In vitro
NPC-15199 [(N-(9-fluorenylmethoxycarbonyl)L-leucine)], a novel anti-inflammatory agent, increases intracellular Ca2+ concentration ([Ca2+]i) in human bladder female transitional cancer (BFTC) cells.?Using fura-2 as a Ca2+ probe, NPC-15199 (0.1-2 mM) was found to increase [Ca2+]i concentration-dependently.?The response saturated at 2-5 mM NPC-15199.?The [Ca2+]i increase comprised an initial rise, a slow decay, and a plateau.?Ca2+ removal partly inhibited the Ca2+ signals.?In Ca2+-free medium, pretreatment with 1 mM NPC-15199 abolished the [Ca2+]i increase induced by 1 microM thapsigargin (an endoplasmic reticulum Ca2+ pump inhibitor);?and after pretreatment with thapsigargin, NPC-15199-induced Ca2+ release was dramatically inhibited.?This indicates that NPC-15199 released internal Ca2+ mostly from the endoplasmic reticulum.?Adding 3 mM Ca2+ increased [Ca2+]i in cells pretreated with 1 mM NPC-15199 in Ca2+-free medium.?Together, the findings suggest that in BFTC bladder cancer cells, NPC-15199 induced Ca2+ release from the endoplasmic reticulum and activating Ca2+ entry.
AliasFMOC-L-Leucine
Chemical Properties
Molecular Weight353.41
FormulaC21H23NO4
Cas No.35661-60-0
SmilesCC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O
Relative Density.1.207 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (70.74 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8296 mL14.1479 mL28.2957 mL141.4787 mL
5 mM0.5659 mL2.8296 mL5.6591 mL28.2957 mL
10 mM0.2830 mL1.4148 mL2.8296 mL14.1479 mL
20 mM0.1415 mL0.7074 mL1.4148 mL7.0739 mL
50 mM0.0566 mL0.2830 mL0.5659 mL2.8296 mL

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