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NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $29 | In Stock |
Description | NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent. |
In vitro | NPC-15199 [(N-(9-fluorenylmethoxycarbonyl)L-leucine)], a novel anti-inflammatory agent, increases intracellular Ca2+ concentration ([Ca2+]i) in human bladder female transitional cancer (BFTC) cells.?Using fura-2 as a Ca2+ probe, NPC-15199 (0.1-2 mM) was found to increase [Ca2+]i concentration-dependently.?The response saturated at 2-5 mM NPC-15199.?The [Ca2+]i increase comprised an initial rise, a slow decay, and a plateau.?Ca2+ removal partly inhibited the Ca2+ signals.?In Ca2+-free medium, pretreatment with 1 mM NPC-15199 abolished the [Ca2+]i increase induced by 1 microM thapsigargin (an endoplasmic reticulum Ca2+ pump inhibitor);?and after pretreatment with thapsigargin, NPC-15199-induced Ca2+ release was dramatically inhibited.?This indicates that NPC-15199 released internal Ca2+ mostly from the endoplasmic reticulum.?Adding 3 mM Ca2+ increased [Ca2+]i in cells pretreated with 1 mM NPC-15199 in Ca2+-free medium.?Together, the findings suggest that in BFTC bladder cancer cells, NPC-15199 induced Ca2+ release from the endoplasmic reticulum and activating Ca2+ entry. |
Alias | FMOC-L-Leucine |
Molecular Weight | 353.41 |
Formula | C21H23NO4 |
Cas No. | 35661-60-0 |
Smiles | CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O |
Relative Density. | 1.207 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (70.74 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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