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NSC622608

NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.

Catalog No. T35362Cas No. 2593254-90-9

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Purity:99.68%

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COA HNMR

NSC622608

Catalog No. T35362Cas No. 2593254-90-9

NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.

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Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$89	In Stock
10 mg	$155	In Stock
25 mg	$313	In Stock
50 mg	$472	In Stock
100 mg	$678	In Stock
1 mL x 10 mM (in DMSO)	$119	In Stock

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Product Introduction

Bioactivity

Description	NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.
In vitro	NSC622608 blocked VISTA signaling in vitro, enhanced T-cell proliferation, and restored T-cell activation in the presence of VISTA-expressing cancer cell lines[1].

Chemical Properties

Molecular Weight	322.24
Formula	C₉H₁₂BrN₃OS₂
Cas No.	2593254-90-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 4.67 mg/mL (14.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1033 mL	15.5164 mL	31.0328 mL	155.1639 mL
5 mM	0.6207 mL	3.1033 mL	6.2066 mL	31.0328 mL
10 mM	0.3103 mL	1.5516 mL	3.1033 mL	15.5164 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Keywords

NSC622608NSC-622608inhibitVISTANSC 622608Inhibitor