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3,5-Dinitrocatechol

Catalog No. T23109Cas No. 7659-29-2

OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.

3,5-Dinitrocatechol

3,5-Dinitrocatechol

Purity: 99.88%
Catalog No. T23109Cas No. 7659-29-2
OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.
Pack SizePriceAvailabilityQuantity
5 mg$54In Stock
10 mg$77In Stock
25 mg$125In Stock
50 mgInquiryIn Stock
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Purity:99.88%
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COA HNMR HPLC
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Product Introduction

Bioactivity
Description
OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.
Targets&IC50
COMT:12 nM
In vitro
OR-486 is highly effective (IC50 = 12 nM) and selective in inhibiting COMT activity in vitro[3].
In vivo
In mouse trachea (β1-AR dominant), significant suppression of ISO-induced relaxation was observed with the addition of OR-486. In GP trachea, in the presence of clorgiline plus OR-486, both normetadrenaline (NMA) and metadrenaline (MA) (10-4 M) significantly suppressed ISO-induced relaxation[1].
Chemical Properties
Molecular Weight200.11
FormulaC6H4N2O6
Cas No.7659-29-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: < 20.01 mg/mL
DMSO: 50 mg/mL (249.86 mM)
H2O: 0.17 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.9973 mL24.9863 mL49.9725 mL249.8626 mL
5 mM0.9995 mL4.9973 mL9.9945 mL49.9725 mL
10 mM0.4997 mL2.4986 mL4.9973 mL24.9863 mL
20 mM0.2499 mL1.2493 mL2.4986 mL12.4931 mL
50 mM0.0999 mL0.4997 mL0.9995 mL4.9973 mL
100 mM0.0500 mL0.2499 mL0.4997 mL2.4986 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

inhibit3,5-Dinitropyrocatechol3,5Dinitrocatecholmolybdenum3,5-DinitrocatecholOR4863,5 DinitrocatecholOR 486InhibitorOR-486
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