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p38 MAPK-IN-1
Catalog No. T16424Cas No. 1006378-90-0
p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel effective and selective inhibitor of p38 MAPK (IC50: 68 nM).
p38 MAPK-IN-1
Catalog No. T16424Cas No. 1006378-90-0
p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel effective and selective inhibitor of p38 MAPK (IC50: 68 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $198 | 8-10 weeks | |
| 5 mg | $347 | 8-10 weeks | |
| 25 mg | $1,140 | 8-10 weeks | |
| 50 mg | $1,490 | 8-10 weeks | |
| 100 mg | $1,990 | 8-10 weeks | |
| 1 mL x 10 mM (in DMSO) | $382 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel effective and selective inhibitor of p38 MAPK (IC50: 68 nM). |
| Targets&IC50 | p38 MAPK:68 nM |
| In vivo | p38 MAPK-IN-1 dose-dependently inhibits TNFα production (ED50: 0.5 mg/kg). p38 MAPK-IN-1 (1 mg/kg for iv and 10 mg/kg for p.o.) has a t1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a Cmax of 5.3 μM for p.o. in male wistar rats[1]. |
| Molecular Weight | 348.35 |
| Formula | C21H14F2N2O |
| Cas No. | 1006378-90-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8.33 mg/mL (23.84 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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