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PAR650097
🥰Excellent
Catalog No. T77402
Alias PAR650097, PAR 650097
PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.
PAR650097
PAR650097
🥰Excellent
Catalog No. T77402Alias PAR650097, PAR 650097
PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.
Product information is being updated, if you want to purchase, please click the bulk custom button.
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Trypsin
TN68729002-07-7
Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin could induce the cell membrane fusion of PDCoV-infected cells through the interaction between the S glycoprotein of PDCoV and pAPN, activate PAR2 and PAR4, and promote cell proliferation and differentiation. Trypsin can be used to promote wound healing and study neurogenic inflammation.
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Vorapaxar
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SCH 530348, MK-5348
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Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
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CitedAtopaxar
ER-172594-00, E5555
T1986751475-53-3In house
Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.
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AY 77
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AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM). AY 77 can promote migration of human breast cancer cells in vitro.
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Vorapaxar sulfate
Zontivity, vorapaxar monosulfate, SCH 530348 sulfate
T3098705260-08-8
Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.
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ML-354
VU0099704, VU 0099704, ML354
T2190189159-60-4
ML-354 (VU0099704) is a selective and potent PAR4 antagonist for the study of cardiovascular disease.
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PAR-2 Activating Peptide acetate
SLIGRL-NH2 acetate, Protease-Activated Receptor-2 Activating Peptide acetate, PAR-2 Activating Peptide acetate(171436-38-7 free base)
TP1046L
PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).
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Protease-Activated Receptor-1, PAR-1 Agonist acetate
T38836L
Protease-Activated Receptor-1, PAR-1 Agonist acetate is a selective proteinase-activated receptor1Â (PAR-1)Â agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist acetate corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2].
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FSLLRY-NH2 TFA(245329-02-6 free base)
TP1904L
FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
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TRAP-6 amide acetate
T38852L
TRAP-6 amide acetate is a PAR-1 thrombin receptor agonist peptide[1].
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tcY-NH2 TFA(327177-34-4 free base)
TP1925L
tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
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LRGILS-NH2 acetate
T22933L
LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.
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Product Introduction
Bioactivity
Chemical Properties
| Description | PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research. |
| Targets&IC50 | PAR2 (Ms):0.22 nM, PAR2 (human):0.58 nm |
| In vitro | PAR650097 has a high affinity for human PAR2 with KD value =833 pM PAR650097 effectively inhibits trypsin-driven activation of PAR2 with IC50 of 0.58 or 0.22 nM, respectively. [1] |
| In vivo | Intravenous administration of PAR650097 (100 mg/kg for 7 days) in rats achieved systemic exposure equivalent to high multiples of IC50 in vitro. The half-life is about 1-2 days. [1] |
| Alias | PAR650097, PAR 650097 |
| Molecular Weight | 145.5 |
| Smiles | #N/A |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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