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PARP1-IN-14
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Catalog No. T79593Cas No. 2098639-70-2
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor with an IC50 of 0.6 ± 0.1 nM, displaying antiproliferative effects on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with IC50 values below 0.3 nM [1].
PARP1-IN-14
😃Good
Catalog No. T79593Cas No. 2098639-70-2
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor with an IC50 of 0.6 ± 0.1 nM, displaying antiproliferative effects on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with IC50 values below 0.3 nM [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor with an IC50 of 0.6 ± 0.1 nM, displaying antiproliferative effects on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with IC50 values below 0.3 nM [1]. |
| Targets&IC50 | PARP1:0.6 nM |
| In vitro | PARP1-IN-14 (compound 19k) significantly inhibits the proliferation of drug-resistant Capan-1 cells (IC 50 < 0.3 nM) [1]. Treatment with PARP1-IN-14 (0-1 μM for 24 hours) induces DNA damage in both parental Capan-1 (BRCA2 −/−) and drug-resistant cells, and triggers cell cycle arrest and apoptosis in both cell types over 0-48 hours [1]. |
| Molecular Weight | 525.53 |
| Formula | C28H24FN7O3 |
| Cas No. | 2098639-70-2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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