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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 8-10 weeks | |
50 mg | $1,980 | 8-10 weeks | |
100 mg | $2,500 | 8-10 weeks |
Description | PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor with an IC50 of 0.6 ± 0.1 nM, displaying antiproliferative effects on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with IC50 values below 0.3 nM [1]. |
Targets&IC50 | PARP1:0.6 nM |
In vitro | PARP1-IN-14 (compound 19k) significantly inhibits the proliferation of drug-resistant Capan-1 cells (IC 50 < 0.3 nM) [1]. Treatment with PARP1-IN-14 (0-1 μM for 24 hours) induces DNA damage in both parental Capan-1 (BRCA2 −/−) and drug-resistant cells, and triggers cell cycle arrest and apoptosis in both cell types over 0-48 hours [1]. |
Molecular Weight | 525.53 |
Formula | C28H24FN7O3 |
Cas No. | 2098639-70-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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