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PF-04217903 phenolsulfonate

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Catalog No. T12418Cas No. 1159490-85-3

PF-04217903 phenolsulfonate is a potent, ATP-competitive inhibitor of c-Met kinase with a Ki of 4.8 nM for human c-Met.

PF-04217903 phenolsulfonate

PF-04217903 phenolsulfonate

😃Good
Catalog No. T12418Cas No. 1159490-85-3
PF-04217903 phenolsulfonate is a potent, ATP-competitive inhibitor of c-Met kinase with a Ki of 4.8 nM for human c-Met.
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Product Introduction

Bioactivity
Description
PF-04217903 phenolsulfonate is a potent, ATP-competitive inhibitor of c-Met kinase with a Ki of 4.8 nM for human c-Met.
Targets&IC50
c-Met (human):ki:4.8 nM
In vitro
PF-04217903 phenolsulfonate inhibits proliferation of c-Met–amplified human GTL-16 gastric carcinoma and H1993 NSCLC cells with IC50 values of 12 and 30 nM, respectively[1].
In vivo
PF-04217903 phenolsulfonate shows a significant dose-dependent reduction of human IL-8 levels in both the U87MG and GTL-16 models and decreases human VEGFA levels in the GTL-16 model. PF-04217903 phenolsulfonate strongly induces phospho-PDGFRβ levels in U87MG xenograft tumors.PF-04217903 phenolsulfonate dose dependently inhibits c-Met, Gab-1, Erk1/2, and AKT phosphorylation and induced apoptosis (cleaved caspase-3) in U87MG xenograft tumors at all dose levels.[1].
Chemical Properties
Molecular Weight546.56
FormulaC25H22N8O5S
Cas No.1159490-85-3
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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