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PI3K/VEGFR2-IN-1
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Catalog No. T72713Cas No. 2851067-08-6
PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting PI3K (IC50: 2.21 μM) and VEGFR2 (IC50: 68 μM), which induces apoptosis and is utilized in cancer research [1].
PI3K/VEGFR2-IN-1
PI3K/VEGFR2-IN-1
😃Good
Catalog No. T72713Cas No. 2851067-08-6
PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting PI3K (IC50: 2.21 μM) and VEGFR2 (IC50: 68 μM), which induces apoptosis and is utilized in cancer research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting PI3K (IC50: 2.21 μM) and VEGFR2 (IC50: 68 μM), which induces apoptosis and is utilized in cancer research [1]. |
| Targets&IC50 | PI3K:2.21 μM, VEGFR2:68 μM |
| In vitro | PI3K/VEGFR2-IN-1 (compound 8; 1.56-100 µM; 24 h; HePG2, MCF-7, Hela, and PC3 cells) dose-dependently inhibits proliferation and, at 10 mg/mL for 24 hours, induces G1/S phase cell cycle arrest and apoptosis in MCF-7 and Hela cells [1]. |
| Molecular Weight | 343.83 |
| Formula | C17H14ClN3OS |
| Cas No. | 2851067-08-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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