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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $73 | In Stock | |
10 mg | $118 | In Stock | |
25 mg | $238 | In Stock | |
50 mg | $353 | In Stock | |
100 mg | $495 | In Stock |
Description | PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively. |
In vitro | PKI-402 causes in vitro growth inhibition of human tumor cell lines derived from a diverse set of human tumor tissues, including breast, brain (glioma), pancreas, and non-small cell lung cancer (NSCLC) tissues[1]. |
In vivo | PKI-402 exhibits antitumor efficacy via intravenous administration in breast [MDA-MB-361: Her2+ and PIK3CA (E545K)], glioma (U87MG and PTEN), and NSCLC (A549; K-Ras and STK11) xenograft models, with induced regression observed specifically in the MDA-MB-361 model. |
Molecular Weight | 570.65 |
Formula | C29H34N10O3 |
Cas No. | 1173204-81-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
Solubility Information | DMSO: 5 mg/mL (8.76 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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