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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $86 | 5 days |
Description | Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs) and can significantly up-regulate CYP3A4 expression and activity via the PXR-mediated pathway. |
In vitro | Praeruptorin B inhibits SREBPs activity, decreases intracellular lipid levels, and reduces SRE-luciferase activity in a dose-dependent manner. It shows negligible cytotoxicity even at higher concentrations and significantly down-regulates the expression of SREBP-1c and SREBP-2 [1]. Praeruptorin B also significantly inhibits UGT1A9 activity [2]. |
In vivo | Mice treated with Praeruptorin B (50 mg/kg) exhibit reduced body weight compared to vehicle-treated mice but remain heavier than chow diet-fed mice. Notably, Praeruptorin B-treated mice display decreased fat/lean and fat/body-weight ratios. Serum TC and TG levels are significantly lower in Praeruptorin B-treated mice compared to HFD-fed mice, with HDL-c increased and LDL-c decreased, similar to lovastatin. Additionally, Praeruptorin B significantly reduces TC and TG levels in the liver and lowers elevated fasting blood glucose and insulin in HFD-fed mice [1]. |
Alias | Praeruptorin D |
Molecular Weight | 426.46 |
Formula | C24H26O7 |
Cas No. | 73069-28-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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