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Ezetimibe ketone
🥰Excellent
Catalog No. T11251Cas No. 191330-56-0
Alias EZM-K
Ezetimibe ketone (EZM-K) is a metabolite of Ezetimibe with antioxidant activity, alleviating H2O2-induced apoptosis and reactive oxygen species (ROS) in NRK-52E cells, upregulating Nrf2 and HO-1 levels.
Ezetimibe ketone
🥰Excellent
Purity: 99.32%
Catalog No. T11251Alias EZM-KCas No. 191330-56-0
Ezetimibe ketone (EZM-K) is a metabolite of Ezetimibe with antioxidant activity, alleviating H2O2-induced apoptosis and reactive oxygen species (ROS) in NRK-52E cells, upregulating Nrf2 and HO-1 levels.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $117 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $422 | In Stock | |
| 25 mg | $872 | In Stock | |
| 50 mg | $1,390 | In Stock |
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Purity:99.32%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ezetimibe ketone (EZM-K) is a metabolite of Ezetimibe with antioxidant activity, alleviating H2O2-induced apoptosis and reactive oxygen species (ROS) in NRK-52E cells, upregulating Nrf2 and HO-1 levels. |
| In vitro | Ezetimibe ketone alleviates H2O2-induced apoptosis and reactive oxygen species (ROS) production in NRK-52E cells, and upregulates Nrf2 and HO-1 levels. [1] |
| In vivo | In rat RIRI models, pretreatment with Ezetimibe ketone activated Nrf2/HO-1 signaling pathway, inhibited renal tubule injury and inflammation, and improved renal function. [1] |
| Alias | EZM-K |
| Molecular Weight | 407.41 |
| Formula | C24H19F2NO3 |
| Cas No. | 191330-56-0 |
| Smiles | C(CC(=O)C1=CC=C(F)C=C1)[C@@H]2[C@H](N(C2=O)C3=CC=C(F)C=C3)C4=CC=C(O)C=C4 |
| Relative Density. | 1.325 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (196.36 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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