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PROTAC KRAS G12C degrader-1
😃Good
Catalog No. T77926
PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells [1].
PROTAC KRAS G12C degrader-1
PROTAC KRAS G12C degrader-1
😃Good
Catalog No. T77926
PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells [1].
| Pack Size | Price | Availability | Quantity |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells [1]. |
| In vitro | PROTAC KRAS G12C degrader-1 (compound 10) binds to CRBN in cells and KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and promotes CRBN-dependent degradation of GFP-KRASG12C in reporter cells [1]. |
| Molecular Weight | 917.47 |
| Formula | C50H54ClFN8O6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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