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PROTAC SMARCA2 degrader-21
🥰Excellent
Catalog No. T201226Cas No. 2891464-61-0
PROTAC SMARCA2 degrader-21 (Compound I-5) acts as a degrader of SMARCA2 in A549 cells, with a DC50 range of 10-50 nM, and additionally degrades both SMARCA2 and SMARCA4 in MV411 cells, with respective DC50 values of <1 nM and >100 nM.
PROTAC SMARCA2 degrader-21
🥰Excellent
Catalog No. T201226Cas No. 2891464-61-0
PROTAC SMARCA2 degrader-21 (Compound I-5) acts as a degrader of SMARCA2 in A549 cells, with a DC50 range of 10-50 nM, and additionally degrades both SMARCA2 and SMARCA4 in MV411 cells, with respective DC50 values of <1 nM and >100 nM.
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC SMARCA2 degrader-21 (Compound I-5) acts as a degrader of SMARCA2 in A549 cells, with a DC50 range of 10-50 nM, and additionally degrades both SMARCA2 and SMARCA4 in MV411 cells, with respective DC50 values of <1 nM and >100 nM. |
| Molecular Weight | 995.24 |
| Formula | C54H66N12O5S |
| Cas No. | 2891464-61-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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