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QPX7728-OH disodium
🥰Excellent
Catalog No. T12603Cas No. 2170848-99-2
Alias Xeruborbactam disodium, QPX7728-OH disodium, QPX 7728 disodium, OMNIvance, BRII-636 disodium, BRII636 disodium
QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases with antibacterial activity, used in research on bacterial infections.
QPX7728-OH disodium
🥰Excellent
Purity: 100%
Catalog No. T12603Alias Xeruborbactam disodium, QPX7728-OH disodium, QPX 7728 disodium, OMNIvance, BRII-636 disodium, BRII636 disodiumCas No. 2170848-99-2
QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases with antibacterial activity, used in research on bacterial infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $417 | In Stock | |
| 5 mg | $988 | In Stock | |
| 10 mg | $1,330 | In Stock | |
| 25 mg | $1,980 | In Stock | |
| 50 mg | $2,670 | In Stock |
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Purity:100%
ee:99.92%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases with antibacterial activity, used in research on bacterial infections. |
| In vitro | The efficacy of QPX7728 disodium against Pseudomonas aeruginosa was not affected by the OprD inactivation of carbapenem porins. In strains with porin mutations, QPX7728 disodium (4 μg/ml) completely reversed KPC-mediated meropenem resistance. [1] The combination of QPX7728 disodium and cefbutin had similar efficacy against all enzyme subgroups (MIC90 of 1-2 μg/mL). [2] |
| In vivo | In a neutropenic mouse model of thigh infection, QPX7728 disodium (12.5, 25, or 50 mg/kg intraperitoneally administered every 2 hours for 24h) was administered in combination with cephalosporins. The bacterial counts of two carbapenem-resistant Klebsiella pneumoniae strains were reduced by about 2 log CFU. [[3] |
| Alias | Xeruborbactam disodium, QPX7728-OH disodium, QPX 7728 disodium, OMNIvance, BRII-636 disodium, BRII636 disodium |
| Molecular Weight | 283.96 |
| Formula | C10H8BFNa2O5 |
| Cas No. | 2170848-99-2 |
| Smiles | [O-]C(C1=C2C([C@@]3([C@@]([H])(C3)[B-](O2)(O)O)[H])=CC=C1F)=O.[Na+].[Na+] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 60 mg/mL (211.3 mM), Sonication is recommended. DMSO: 80 mg/mL (281.73 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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