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Ragaglitazar
🥰Excellent
Catalog No. T28501Cas No. 222834-30-2
Alias NNC61-0029, NNC-61-0029, NNC 61-0029, NN-622, NN 622, (-)-DRF-2725
Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα, which shows improved insulin sensitization and lipid-lowering potential in animal models and can be used to study type 2 diabetes.
Ragaglitazar
🥰Excellent
Purity: 99.33%
Catalog No. T28501Alias NNC61-0029, NNC-61-0029, NNC 61-0029, NN-622, NN 622, (-)-DRF-2725Cas No. 222834-30-2
Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα, which shows improved insulin sensitization and lipid-lowering potential in animal models and can be used to study type 2 diabetes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $639 | In Stock | |
| 5 mg | $1,370 | In Stock | |
| 25 mg | $2,230 | In Stock | |
| 50 mg | $2,780 | In Stock | |
| 100 mg | $3,700 | In Stock |
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Purity:99.33%
ee:96.428%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα, which shows improved insulin sensitization and lipid-lowering potential in animal models and can be used to study type 2 diabetes. |
| In vitro | METHODS: A comparative dose-response study of PPARγ and PPARα was performed using Ragaglitazar (NNC-61-0029) (0.1, 1, 10, 100 nM). RESULTS Ragaglitazar (NNC-61-0029) showed significant activation of both isoforms. Ragaglitazar showed weaker potency against PPARγ (EC50=324 nm) and more potent activation of PPARα (EC50=270 nm). [1] |
| In vivo | METHODS: SD rats fed a high-fat diet were treated with Ragaglitazar (NNC-61-0029) (0.1, 0.3, 1, 10, 30 mg/kg) to observe the improvement of blood lipid levels in rats. RESULTS Rats showed a dose-dependent improvement in plasma lipid levels, and plasma Apo CIII levels were significantly reduced in ragaglitazar (10 mg/kg) (P<0.05). [1] |
| Alias | NNC61-0029, NNC-61-0029, NNC 61-0029, NN-622, NN 622, (-)-DRF-2725 |
| Molecular Weight | 419.47 |
| Formula | C25H25NO5 |
| Cas No. | 222834-30-2 |
| Smiles | C(COC1=CC=C(C[C@H](OCC)C(O)=O)C=C1)N2C=3C(OC=4C2=CC=CC4)=CC=CC3 |
| Relative Density. | 1.241 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (119.2 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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