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Rezivertinib
🥰Excellent
Catalog No. T36644Cas No. 1835667-12-3
Alias BPI-7711, BPI7711
Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders.
Rezivertinib
🥰Excellent
Purity: 99.43%
Catalog No. T36644Alias BPI-7711, BPI7711Cas No. 1835667-12-3
Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $109 | In Stock | |
| 5 mg | $238 | In Stock | |
| 10 mg | $383 | In Stock | |
| 25 mg | $739 | In Stock | |
| 50 mg | $996 | In Stock | |
| 100 mg | $1,330 | In Stock | |
| 200 mg | $1,790 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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Purity:99.43%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Rezivertinib (BPI-7711) is an orally available, selective and potent inhibitor of tyrosine kinase (EGFR) with antitumor activity for central nervous system disorders. |
| Targets&IC50 | HCC827 cells:6.8 nM (GI50), A431 cells:>1000 nM (GI50), NCI-H1975 cells:22 nM (GI50), PC9 cells:13.3 nM (GI50) |
| In vitro | Rezivertinib selectively inhibits cellular proliferation of EGFR mutations in cell lines: PC9 (GI50=13.3 nM), HCC827 (GI50=6.8 nM), NCI-H1975 (GI50=22 nM) and A431 (GI50>1000 nM). [1] |
| In vivo | Rezivertinib administered orally for 14 days at 6.25-25 mg/kg/day demonstrated significant tumor regression. In addition, Rezivertinib administered orally at 50 mg/kg/day also showed anti-tumor effects, significantly improving the mean overall survival of the animals, which was prolonged from 13 to 28 days, a 115% improvement. [2] |
| Alias | BPI-7711, BPI7711 |
| Molecular Weight | 486.57 |
| Formula | C27H30N6O3 |
| Cas No. | 1835667-12-3 |
| Smiles | O=C(C=C)NC1=CC(NC=2N=CC=C(N2)C3=CN(C=4C=CC=CC34)C)=C(OC)C=C1OCCN(C)C |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL, (205.52 mM.), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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