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Safironil

🥰Excellent
Catalog No. T67961Cas No. 134377-69-8

safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin levels, and fibrogenesis as judged by type I and type III collagen and laminin production. safironil had no effect on the size of liver granulomas without altering total hydroxyproline, but altered the pattern of fibrosis by increasing type III and decreasing type I collagen deposition.

Safironil

Safironil

🥰Excellent
Purity: 99.51%
Catalog No. T67961Cas No. 134377-69-8
safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin levels, and fibrogenesis as judged by type I and type III collagen and laminin production. safironil had no effect on the size of liver granulomas without altering total hydroxyproline, but altered the pattern of fibrosis by increasing type III and decreasing type I collagen deposition.
Pack SizePriceAvailabilityQuantity
1 mg$97 In Stock
5 mg$230 In Stock
10 mg$340 In Stock
25 mg$586 In Stock
50 mg$838 In Stock
100 mg$1,160 In Stock
500 mg$2,320 In Stock
1 mL x 10 mM (in DMSO)$232 In Stock
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Purity:99.51%
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Product Introduction

Bioactivity
Description
safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin levels, and fibrogenesis as judged by type I and type III collagen and laminin production. safironil had no effect on the size of liver granulomas without altering total hydroxyproline, but altered the pattern of fibrosis by increasing type III and decreasing type I collagen deposition.
In vitro
HOE 77, Safironil, and S 4682 are inhibitors of prolyl 4-hydroxylase, which is essential for thecollagen formation. Although HOE 77, Safironil, and S 4682 seem to work by inhibiting HSC activation, further studies will be required before their clinical application. alpha-Tocopherol, retinyl palmitate, and silybinin reduce lipid peroxidation and attenuate HSC activation in experimental models.[2]
In vivo
The present studies evaluate the mechanism of action of two novel antifibrotic compounds, HOE 077 and Safironil, which were designed as competitive inhibitors of collagen protein synthesis. Stellate cell activation, rather than collagen synthesis, proved to be the target of both HOE 077 and Safironil in the intact liver. In culture, the drugs not only prevented the activation of stellate cells but also accelerated their deactivation. They were no more effective in co-cultures containing hepatocytes than in pure stellate cell cultures, indicating that metabolic conversion of HOE 077 was not required. Interestingly, the response of cells from females was greater than that of male cells, leading to the conclusion that stellate activation is sexually dimorphic. This finding may be relevant to the observation that fibrosis in chronic viral hepatitis progresses less rapidly and that hepatocellular carcinoma is less frequent in females than in males.[1]
Chemical Properties
Molecular Weight309.36
FormulaC15H23N3O4
Cas No.134377-69-8
SmilesC(NCCCOC)(=O)C=1C=C(C(NCCCOC)=O)N=CC1
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (96.97 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2325 mL16.1624 mL32.3248 mL161.6240 mL
5 mM0.6465 mL3.2325 mL6.4650 mL32.3248 mL
10 mM0.3232 mL1.6162 mL3.2325 mL16.1624 mL
20 mM0.1616 mL0.8081 mL1.6162 mL8.0812 mL
50 mM0.0646 mL0.3232 mL0.6465 mL3.2325 mL

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