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Satraplatin

Catalog No. T7221Cas No. 129580-63-8
Alias JM216, BMY45594, BMS182751

Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.

Satraplatin

Satraplatin

Catalog No. T7221Alias JM216, BMY45594, BMS182751Cas No. 129580-63-8
Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
Pack SizePriceAvailabilityQuantity
1 mg$100In Stock
5 mg$247In Stock
10 mg$396In Stock
25 mg$648In Stock
50 mg$892In Stock
100 mg$1,230In Stock
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Purity:≥95%
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Product Introduction

Bioactivity
Description
Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical activity against a variety of malignancies.
In vitro
KB-R cells did not show cross-resistance to satraplatin. The expression status of almost all transporters was upregulated in the KB-R cells. There was no difference in the GSH levels between the KB and KB-R cells. Flow cytometric analysis indicated that with satraplatin the G2/M phase was arrested in the KB-R cells. KB-R cells contain enriched side population cells[1].
Cell Research
CDDP-resistant (KB-R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real-time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment[1].
AliasJM216, BMY45594, BMS182751
Chemical Properties
Molecular Weight500.28
FormulaC10H22Cl2N2O4Pt
Cas No.129580-63-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 33 mg/mL (65.96 mM), DMSO inactivates the activity of Satraplatin.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9989 mL9.9944 mL19.9888 mL99.9440 mL
5 mM0.3998 mL1.9989 mL3.9978 mL19.9888 mL
10 mM0.1999 mL0.9994 mL1.9989 mL9.9944 mL
20 mM0.0999 mL0.4997 mL0.9994 mL4.9972 mL
50 mM0.0400 mL0.1999 mL0.3998 mL1.9989 mL

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