Shopping Cart
- Remove All
Your shopping cart is currently empty
SCH79797
🥰Excellent
Catalog No. T28734Cas No. 245520-69-8
Alias SCH-79797, SCH 79797
SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonist with an IC50=70 nM with antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects that attenuates thrombin-induced increase in CH25H expression in astrocytes, inhibits peritoneal dissemination of gastric cancer, and attenuates repetitive traumatic brain injury.
SCH79797
🥰Excellent
Purity: 99.80%
Catalog No. T28734Alias SCH-79797, SCH 79797Cas No. 245520-69-8
SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonist with an IC50=70 nM with antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects that attenuates thrombin-induced increase in CH25H expression in astrocytes, inhibits peritoneal dissemination of gastric cancer, and attenuates repetitive traumatic brain injury.
Product information is being updated, if you want to purchase, please click the bulk custom button.
Bulk & Custom
Questions
View MoreInhibitors Related to "SCH79797"
LRGILS-NH2 acetate
T22933L
LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.
- $35
Size
QTY
Trypsin
TN68729002-07-7
Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin could induce the cell membrane fusion of PDCoV-infected cells through the interaction between the S glycoprotein of PDCoV and pAPN, activate PAR2 and PAR4, and promote cell proliferation and differentiation. Trypsin can be used to promote wound healing and study neurogenic inflammation.
- $39
Size
QTY
Protease-Activated Receptor-1, PAR-1 Agonist acetate
T38836L
Protease-Activated Receptor-1, PAR-1 Agonist acetate is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist acetate corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2].
- $133
Size
QTY
AY 77
Unk-Cha-Chg-NH2
T411901835734-92-3In house
AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM). AY 77 can promote migration of human breast cancer cells in vitro.
- $412
Size
QTY
PAR-2 Activating Peptide acetate
SLIGRL-NH2 acetate, Protease-Activated Receptor-2 Activating Peptide acetate, PAR-2 Activating Peptide acetate(171436-38-7 free base)
TP1046L
PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).
- $78
Size
QTY
VKGILS-NH2 Acetate
VKGILS-NH2 Acetate (942413-05-0 Free base)
T21699L
VKGILS-NH2 Acetate is a reversed amino acid sequence control peptide for SLIGKV-NH2, a protease-activated receptor 2 (PAR2) agonist.
- $29
Size
QTY
Atopaxar
ER-172594-00, E5555
T1986751475-53-3In house
Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.
- $67
Size
QTY
Vorapaxar
Cited
SCH 530348, MK-5348
T7013618385-01-6
Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
- $68
Size
QTY
CitedVorapaxar sulfate
Zontivity, vorapaxar monosulfate, SCH 530348 sulfate
T3098705260-08-8
Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.
- $32
Size
QTY
PAR-2-IN-1
IUN76750
T89171690176-75-0
PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
- $30
Size
QTY
FSLLRY-NH2 TFA(245329-02-6 free base)
TP1904L
FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
- $98
Size
QTY
ML-354
VU0099704, VU 0099704, ML354
T2190189159-60-4
ML-354 (VU0099704) is a selective and potent PAR4 antagonist for the study of cardiovascular disease.
- $50
Size
QTY
Select Batch
Purity:99.80%
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonist with an IC50=70 nM with antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects that attenuates thrombin-induced increase in CH25H expression in astrocytes, inhibits peritoneal dissemination of gastric cancer, and attenuates repetitive traumatic brain injury. |
| In vivo | Methods: SCH79797 (2.5, 10, 25, 50, 100 and 250 μg/kg, intravenously) was administered to rats and subjected to 30 min of ischemia and 180 min of reperfusion to investigate its cardioprotective effects in vivo. Results: Infarct size, expressed as a percentage of area at risk (AAR), was 62 ± 3 % of the AAR in the control group; no significant changes in infarct size were observed at the lowest (2.5 μg/kg) and highest (250 μg/kg) doses of SCH79797; however, a gradual decrease was observed at doses of 10-100 μg/kg, with 25 μg/kg being the most effective dose. [1] |
| Alias | SCH-79797, SCH 79797 |
| Molecular Weight | 371.48 |
| Formula | C23H25N5 |
| Cas No. | 245520-69-8 |
| Smiles | N=1C(=NC2=CC=C3C(C=CN3CC4=CC=C(C=C4)C(C)C)=C2C1N)NC5CC5 |
| Relative Density. | 1.32 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy SCH79797 | purchase SCH79797 | SCH79797 cost | order SCH79797 | SCH79797 chemical structure | SCH79797 in vivo | SCH79797 formula | SCH79797 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.