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SIAIS100 TFA
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Catalog No. T77969
SIAIS100 TFA is a potent BCR-ABL PROTAC degrader with a DC50 of 2.7 nM, used in chronic myeloid leukemia (CML) research [1].
SIAIS100 TFA
SIAIS100 TFA
😃Good
Catalog No. T77969
SIAIS100 TFA is a potent BCR-ABL PROTAC degrader with a DC50 of 2.7 nM, used in chronic myeloid leukemia (CML) research [1].
| Pack Size | Price | Availability | Quantity |
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SIAIS100 TFA is a potent BCR-ABL PROTAC degrader with a DC50 of 2.7 nM, used in chronic myeloid leukemia (CML) research [1]. |
| In vitro | SIAIS100 exhibits antiproliferative activity against K562 cells with an IC50 value of 12 nM [1]. It induces degradation of BCR-ABL by 81.78% and 91.20% at concentrations of 5 nM and 100 nM, respectively [1]. SIAIS100 (100 nM; 8 h) significantly decreases BCR-ABL in K562 cells [1]. SIAIS100 (100 nM; 6 h) causes persistent and robust degradation of BCR-ABL, maintaining a durable cellular response post drug removal [1]. Additionally, SIAIS100 (1-1000 nM) significantly reduces mutant G250E/T315I in a dose-dependent manner and inhibits BCR-ABL signaling in 32D cells, as assessed by p-BCR-ABL levels [1]. |
| Molecular Weight | 1004.46 |
| Formula | C46H51ClF5N9O7S |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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