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SJ995973
🥰Excellent
Catalog No. T77933Cas No. 2882065-25-8
Alias SJ-995973, SJ 995973
SJ995973 is a highly potent bromodomain and extraterminal (BET) protein degrader and a BET PROTAC with potential anticancer activity.
SJ995973
🥰Excellent
Catalog No. T77933Alias SJ-995973, SJ 995973Cas No. 2882065-25-8
SJ995973 is a highly potent bromodomain and extraterminal (BET) protein degrader and a BET PROTAC with potential anticancer activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $228 | In Stock | |
| 5 mg | $689 | In Stock | |
| 10 mg | $1,180 | In Stock | |
| 25 mg | $1,780 | In Stock | |
| 50 mg | $2,380 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SJ995973 is a highly potent bromodomain and extraterminal (BET) protein degrader and a BET PROTAC with potential anticancer activity. |
| Targets&IC50 | MV4-11 cells:3 pM, BRD4:0.87 nM (DC50) |
| In vitro | SJ995973 was a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins. SJ995973 inhibited the viability of human acute myeloid leukemia MV4-11 cells at low picomolar concentrations, IC50 = 3 pM, BRD4 DC50 = 0.87 nM. [1] |
| Alias | SJ-995973, SJ 995973 |
| Molecular Weight | 730.28 |
| Formula | C37H40ClN7O5S |
| Cas No. | 2882065-25-8 |
| Smiles | CC=1C2=C(N3C([C@H](CC(NCCCCCNC(COC4=CC=C(C=C4)C5C(=O)NC(=O)CC5)=O)=O)N=C2C6=CC=C(Cl)C=C6)=NN=C3C)SC1C |
Storage & Solubility Information
| Storage | store under nitrogen | store at 4°C | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL(109.55 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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