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SLC26A3-IN-2
🥰Excellent
Catalog No. T74815Cas No. 950348-60-4
SLC26A3-IN-2 is an orally available and highly potent inhibitor of the anion-exchange protein SLC26A3 for the study of constipation. dCMP disodium (2'2'') is a potent inhibitor of the anion-exchange protein SLC26A3.
SLC26A3-IN-2
🥰Excellent
Purity: 100%
Catalog No. T74815Cas No. 950348-60-4
SLC26A3-IN-2 is an orally available and highly potent inhibitor of the anion-exchange protein SLC26A3 for the study of constipation. dCMP disodium (2'2'') is a potent inhibitor of the anion-exchange protein SLC26A3.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SLC26A3-IN-2 is an orally available and highly potent inhibitor of the anion-exchange protein SLC26A3 for the study of constipation. dCMP disodium (2'2'') is a potent inhibitor of the anion-exchange protein SLC26A3. |
| Targets&IC50 | SLC26A3:360 nM |
| In vitro | SLC26A3-IN-2 is an orally active inhibitor of the anion-exchange protein SLC26A3 with an IC50 of 360 nM. 92% inhibition of SLC26A3 was achieved when SLC26A3-IN-2 was treated for 10 min at a concentration of 10 μM. [1] |
| In vivo | Oral administration of 10 mg/kg SLC26A3-IN-2 significantly increased the weight of feces and the number of particles in a loperamide-induced constipation model in mice, showing its effect in increasing fecal hydration capacity in mice. [1] |
| Molecular Weight | 368.84 |
| Formula | C19H13ClN2O2S |
| Cas No. | 950348-60-4 |
| Smiles | O=C1C=C(N=C2SC=C(C=3C=CC=CC3)N12)COC=4C=CC=CC4Cl |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (27.11 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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