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SMBA1
🥰Excellent
Catalog No. T8792Cas No. 906440-37-7
SMBA1 is a highly potent Bax agonist with antitumor activity that induces cell cycle arrest and apoptosis in malignant glioma cells. SMBA1 can be used to study triple-negative breast cancer.
SMBA1
🥰Excellent
Purity: 99.2%
Catalog No. T8792Cas No. 906440-37-7
SMBA1 is a highly potent Bax agonist with antitumor activity that induces cell cycle arrest and apoptosis in malignant glioma cells. SMBA1 can be used to study triple-negative breast cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $238 | In Stock | |
| 10 mg | $349 | In Stock | |
| 25 mg | $568 | In Stock | |
| 50 mg | $793 | In Stock | |
| 100 mg | $1,090 | In Stock | |
| 500 mg | $2,190 | In Stock |
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Purity:99.2%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SMBA1 is a highly potent Bax agonist with antitumor activity that induces cell cycle arrest and apoptosis in malignant glioma cells. SMBA1 can be used to study triple-negative breast cancer. |
| In vitro | SMBA1 exhibited Bax agonist activity by inhibiting the phosphorylation of S184, promoting the insertion of Bax into the mitochondrial membrane and the formation of Bax oligomers, and thereby inducing conformational changes in Bax. SMBA1 (0, 0.1, 1, 5, 10 µM; 24 hr) potentiated Bax expression in a dose-dependent manner in A549 cells. [1] |
| In vivo | SMBA1 (2, 10, 40, 60 mg/kg; intraperitoneal injection; once daily for 10 days) exhibited antitumor activity in mice. [1] |
| Molecular Weight | 315.32 |
| Formula | C20H13NO3 |
| Cas No. | 906440-37-7 |
| Smiles | O=[N+]([O-])C1=CC2=C(C3=CC=CC=C3C2=CC4=C(O)C=CC=C4)C=C1 |
| Relative Density. | 1.392 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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