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SP-13786 is an inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 values ​​of 3.2 nM and 1.8 μM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 63 € | In Stock | |
5 mg | 168 € | In Stock | |
10 mg | 263 € | In Stock | |
25 mg | 501 € | In Stock | |
50 mg | 724 € | In Stock | |
100 mg | 1.016 € | In Stock | |
1 mL x 10 mM (in DMSO) | 176 € | In Stock |
Description | SP-13786 is an inhibitor of fibroblast activation protein (FAP) and prolyl oligopeptidase (PREP) with IC50 values ​​of 3.2 nM and 1.8 μM, respectively. |
Targets&IC50 | PREP:1.8 μM, FAP:3.2 nM |
In vivo | METHODS: SP-13786 (UAMC-1110) (20 mg/kg, orally, twice a day) was used to treat Panc02-SIY cell tumor xenograft mice, and its effect on tumors in the mice was observed. RESULTS Tumor-infiltrating macrophages were reduced during UAMC-1110 administration, and UAMC-1110 significantly increased tumor-infiltrating CD8 T cells, including effector subsets. [2] |
Alias | UAMC-1110 |
Molecular Weight | 344.32 |
Formula | C17H14F2N4O2 |
Cas No. | 1448440-52-5 |
Smiles | C(NCC(=O)N1[C@H](C#N)CC(F)(F)C1)(=O)C=2C3=C(N=CC2)C=CC=C3 |
Relative Density. | 1.42 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (290.43 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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