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SR-1277

Name: SR-1277
Brand: TargetMol
SKU: T38927
Rating: 4.5 (1 reviews)

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Catalog No. T38927Cas No. 1446715-47-4

SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. Taken together, SR-1277 represents a valuable tool for cancer research.

SR-1277

😃Good

Catalog No. T38927Cas No. 1446715-47-4

Pack Size	Price	Availability	Quantity
5 mg	$970	4-6 weeks

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Product Introduction

Bioactivity

Description	SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. Taken together, SR-1277 represents a valuable tool for cancer research.
Targets&IC50	CKIδ:49 nM (IC50), CKIϵ:260 nM (IC50)
In vitro	SR-1277 demonstrates antiproliferative effects in A375 cells with an EC50 of 22 nM[1].
In vivo	SR-1277, administered intravenously at a dose of 1 mg/kg, demonstrates a peak concentration (C max) of 1.2 μM, a clearance rate (Cl) of 2.8 ml/min/kg, an area under the curve (AUC) of 1.26 μM·h, a half-life (T 1/2) of 1.42 hours, and a brain penetration rate of 24% in mice[1].

Chemical Properties

Molecular Weight	477.5
Formula	C₂₁H₁₉N₉O₃S
Cas No.	1446715-47-4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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