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SR-1277
🥰Excellent
Catalog No. T38927Cas No. 1446715-47-4
Alias SR1277
SR-1277 is a potent, highly selective and ATP-competitive CK1δ/ε inhibitor with IC50 values of 49 nM and 260 nM, respectively.CK1δ plays a crucial role in regulating Wee1 activity at the G2/M cell-cycle interface, and exhibits significant antiproliferative activity against a variety of cancer cells.
SR-1277
🥰Excellent
Catalog No. T38927Alias SR1277Cas No. 1446715-47-4
SR-1277 is a potent, highly selective and ATP-competitive CK1δ/ε inhibitor with IC50 values of 49 nM and 260 nM, respectively.CK1δ plays a crucial role in regulating Wee1 activity at the G2/M cell-cycle interface, and exhibits significant antiproliferative activity against a variety of cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $397 | In Stock | |
| 5 mg | $970 | In Stock | |
| 10 mg | $1,290 | In Stock | |
| 25 mg | $1,950 | In Stock | |
| 50 mg | $2,620 | In Stock | |
| 100 mg | $3,530 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SR-1277 is a potent, highly selective and ATP-competitive CK1δ/ε inhibitor with IC50 values of 49 nM and 260 nM, respectively.CK1δ plays a crucial role in regulating Wee1 activity at the G2/M cell-cycle interface, and exhibits significant antiproliferative activity against a variety of cancer cells. |
| Targets&IC50 | CKIδ:49 nM, CKIϵ:260 nM |
| In vitro | Methods: A375 cells were treated with SR-1277 and cell viability was determined by MTT assay. Results: SR-1277 showed antiproliferative effects in A375 cells with an EC50 value of 22 nM. [1] |
| In vivo | Methods: SR-1277 (1 mg/kg, intravenous injection) was administered to mice, and an in vivo PK study was performed. Results: The Cmax value of SR-1277 in mice was 1.2 μM, the Cl value was 2.8 ml/min/kg, the AUC value was 1.26 μM•h, and the half-life was 1.42 h. [1] |
| Alias | SR1277 |
| Molecular Weight | 477.5 |
| Formula | C21H19N9O3S |
| Cas No. | 1446715-47-4 |
| Smiles | O=[N+](C1=CC=CC2=C1NC(CNC3=NC(N4CCOCC4)=NC5=C3N=CN5C6=CSC=C6)=N2)[O-] |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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