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SR-1277

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Catalog No. T38927Cas No. 1446715-47-4

SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. Taken together, SR-1277 represents a valuable tool for cancer research.

SR-1277

SR-1277

😃Good
Catalog No. T38927Cas No. 1446715-47-4
SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. Taken together, SR-1277 represents a valuable tool for cancer research.
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5 mg$9706-8 weeks
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Product Introduction

Bioactivity
Description
SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. Taken together, SR-1277 represents a valuable tool for cancer research.
Targets&IC50
CKIδ:49 nM (IC50), CKIϵ:260 nM (IC50)
In vitro
SR-1277 demonstrates antiproliferative effects in A375 cells with an EC50 of 22 nM[1].
In vivo
SR-1277, administered intravenously at a dose of 1 mg/kg, demonstrates a peak concentration (C max) of 1.2 μM, a clearance rate (Cl) of 2.8 ml/min/kg, an area under the curve (AUC) of 1.26 μM·h, a half-life (T 1/2) of 1.42 hours, and a brain penetration rate of 24% in mice[1].
Chemical Properties
Molecular Weight477.5
FormulaC21H19N9O3S
Cas No.1446715-47-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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