Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 105.00 | |
10 mg | In stock | $ 148.00 | |
25 mg | In stock | $ 241.00 | |
50 mg | In stock | $ 355.00 |
Description | TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases. |
In vitro | TBCA inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM. TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability [1]. TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including CRP, 2-MeSADP, AYPGKF and SFLLRN. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF[2]. |
Synonyms | Casein Kinase II Inhibitor III, TBCA |
Molecular Weight | 463.74 |
Formula | C9H4Br4O2 |
CAS No. | 934358-00-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (194.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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TBCA 934358-00-6 Metabolism Stem Cells Casein Kinase Casein Kinase II Inhibitor III, TBCA inhibitor inhibit