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Succinyl phosphonate
🥰Excellent
Catalog No. T13020Cas No. 26647-82-5
Succinyl phosphonate is a selective α-ketoglutarate dehydrogenase (α-KGDHC ) and OGDHC inhibitor that inhibits α-ketoglutarate oxidative decarboxylation. Succinyl phosphonate trisodium salt inhibits glutamate-induced ROS generation in glutamate-stimulated hippocampal neurons and can be used to study neurodegenerative diseases.
Succinyl phosphonate
🥰Excellent
Catalog No. T13020Cas No. 26647-82-5
Succinyl phosphonate is a selective α-ketoglutarate dehydrogenase (α-KGDHC ) and OGDHC inhibitor that inhibits α-ketoglutarate oxidative decarboxylation. Succinyl phosphonate trisodium salt inhibits glutamate-induced ROS generation in glutamate-stimulated hippocampal neurons and can be used to study neurodegenerative diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Succinyl phosphonate is a selective α-ketoglutarate dehydrogenase (α-KGDHC ) and OGDHC inhibitor that inhibits α-ketoglutarate oxidative decarboxylation. Succinyl phosphonate trisodium salt inhibits glutamate-induced ROS generation in glutamate-stimulated hippocampal neurons and can be used to study neurodegenerative diseases. |
| In vitro | Succinyl phosphonate (0.01 mM) completely inhibits isolated brain KGDHC even in the presence of a 200-fold higher concentration of its substrate. In cultured human fibroblasts, 0.01 mM Succinyl phosphonate produced 70% inhibition of α-ketoglutarate dehydrogenase complex. [2] Succinyl phosphonate inhibits 2-Oxoglutarate dehydrogenase, the first rate-limiting component of the mitochondrial multi-enzyme complex of oxidative decarboxylation of 2-oxoglutarate, in a highly selective and efficient manner. [3] |
| Molecular Weight | 182.07 |
| Formula | C4H7O6P |
| Cas No. | 26647-82-5 |
| Smiles | O=C(O)CCC(=O)P(=O)(O)O |
| Relative Density. | 1.726 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 30 mg/mL (164.77 mM.), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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