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T3Inh-1

🥰Excellent
Catalog No. T9720Cas No. 50440-30-7

T3Inh-1 is a potent and selective ppGalNAc-T3 inhibitor with IC50 of 7 µM. T3Inh-1 protects against breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in tissue cells and mice without causing any toxic side effects.

T3Inh-1

T3Inh-1

🥰Excellent
Purity: 97.32%
Catalog No. T9720Cas No. 50440-30-7
T3Inh-1 is a potent and selective ppGalNAc-T3 inhibitor with IC50 of 7 µM. T3Inh-1 protects against breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in tissue cells and mice without causing any toxic side effects.
Pack SizePriceAvailabilityQuantity
1 mg$115In Stock
5 mg$289In Stock
10 mg$478In Stock
25 mg$789In Stock
50 mg$1,080In Stock
100 mg$1,480In Stock
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Purity:97.32%
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Product Introduction

Bioactivity
Description
T3Inh-1 is a potent and selective ppGalNAc-T3 inhibitor with IC50 of 7 µM. T3Inh-1 protects against breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in tissue cells and mice without causing any toxic side effects.
Targets&IC50
ppGalNAc-T3:7 µM
In vitro
METHODS: Breast cancer MDA-MB231 cells were treated with T3Inh-1 (5μM, 24/48 hours) to observe cell proliferation and cell invasion.
RESULTS T3Inh-1 was significantly effective, inhibiting migration by >80% and invasion by 98%, but had no significant effect on cell proliferation. [1]
In vivo
METHODS: Mice were injected intraperitoneally with T3Inh-1 and serum cleaved FGF23 levels were measured. Three groups of T3Inh-1 (25 and 50 mg/kg, intraperitoneal injection, 24 hours) were administered and serum cleaved FGF23 levels were measured.
RESULTS T3Inh-1 resulted in a robust and statistically significant increase in this ratio at the tested concentrations of 25 and 50 mg/kg, suggesting that T3Inh-1 can mitigate the effects of elevated FGF23 signaling in patients with chronic kidney disease. [1]
Chemical Properties
Molecular Weight476.49
FormulaC27H20N6O3
Cas No.50440-30-7
SmilesN(C=1C2=C(C=CC(N(=O)=O)=C2)N=CC1)C3=CC=C(C(NC4=CC=C(NC=5C=CN=CC5)C=C4)=O)C=C3
Relative Density.1.431 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.76 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0987 mL10.4934 mL20.9868 mL104.9340 mL
5 mM0.4197 mL2.0987 mL4.1974 mL20.9868 mL
10 mM0.2099 mL1.0493 mL2.0987 mL10.4934 mL

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