Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 µM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 115.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 478.00 | |
25 mg | In stock | $ 789.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,480.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 296.00 |
Description | T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 µM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. |
Targets&IC50 | ppGalNAc-T3:7 µM |
In vitro | In HEK cells, T3Inh-1 (6h)increased the cleavage of FGF2In MDA-MB231 cells, T3Inh-1(5 µM; 24h, 48h) inhibited migration by >80% and invasion by 98% while causing no discernable effect on cell proliferation. T3Inh-1 exhibited no toxicity and did not affect HEK cell proliferation[1]. |
In vivo | In Wild-type C57BL/6 mice, T3Inh-1 (25, 50 mg/kg; i.p.) blocked ppGalNAc-T3-mediated glycan-masking of FGF23 and increased its cleavage[1]. |
Molecular Weight | 476.49 |
Formula | C27H20N6O3 |
CAS No. | 50440-30-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.76 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
T3Inh-1 50440-30-7 Others T3Inh1 T3Inh 1 inhibit O-glycosylation Inhibitor T-3Inh-1 ppGalNAc-T3 breast cancer cells FGF23 invasion inhibitor