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T3Inh-1 is a potent and selective ppGalNAc-T3 inhibitor with IC50 of 7 µM. T3Inh-1 protects against breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in tissue cells and mice without causing any toxic side effects.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $115 | In Stock | |
5 mg | $289 | In Stock | |
10 mg | $478 | In Stock | |
25 mg | $789 | In Stock | |
50 mg | $1,080 | In Stock | |
100 mg | $1,480 | In Stock |
Description | T3Inh-1 is a potent and selective ppGalNAc-T3 inhibitor with IC50 of 7 µM. T3Inh-1 protects against breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in tissue cells and mice without causing any toxic side effects. |
Targets&IC50 | ppGalNAc-T3:7 µM |
In vitro | METHODS: Breast cancer MDA-MB231 cells were treated with T3Inh-1 (5μM, 24/48 hours) to observe cell proliferation and cell invasion. RESULTS T3Inh-1 was significantly effective, inhibiting migration by >80% and invasion by 98%, but had no significant effect on cell proliferation. [1] |
In vivo | METHODS: Mice were injected intraperitoneally with T3Inh-1 and serum cleaved FGF23 levels were measured. Three groups of T3Inh-1 (25 and 50 mg/kg, intraperitoneal injection, 24 hours) were administered and serum cleaved FGF23 levels were measured. RESULTS T3Inh-1 resulted in a robust and statistically significant increase in this ratio at the tested concentrations of 25 and 50 mg/kg, suggesting that T3Inh-1 can mitigate the effects of elevated FGF23 signaling in patients with chronic kidney disease. [1] |
Molecular Weight | 476.49 |
Formula | C27H20N6O3 |
Cas No. | 50440-30-7 |
Smiles | N(C=1C2=C(C=CC(N(=O)=O)=C2)N=CC1)C3=CC=C(C(NC4=CC=C(NC=5C=CN=CC5)C=C4)=O)C=C3 |
Relative Density. | 1.431 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4.76 mg/mL (10 mM), Sonication is recommended. ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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