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T3Inh-1

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T3Inh-1

Catalog No. T9720Cas No. 50440-30-7

T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 µM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects.

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Pack Size	Price	Availability
1 mg	$115	In Stock
5 mg	$289	In Stock
10 mg	$478	In Stock
25 mg	$789	In Stock
50 mg	$1,080	In Stock
100 mg	$1,480	In Stock
1 mL x 10 mM (in DMSO)	$296	In Stock

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Product Introduction

Bioactivity

Description	T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 µM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects.
In vitro	In HEK cells, T3Inh-1 (6h)increased the cleavage of FGF2In MDA-MB231 cells, T3Inh-1(5 µM; 24h, 48h) inhibited migration by >80% and invasion by 98% while causing no discernable effect on cell proliferation. T3Inh-1 exhibited no toxicity and did not affect HEK cell proliferation[1].
In vivo	In Wild-type C57BL/6 mice, T3Inh-1 (25, 50 mg/kg; i.p.) blocked ppGalNAc-T3-mediated glycan-masking of FGF23 and increased its cleavage[1].

Chemical Properties

Molecular Weight	476.49
Formula	C27H20N6O3
Cas No.	50440-30-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.76 mg/mL (10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0987 mL	10.4934 mL	20.9868 mL	104.9340 mL
5 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9868 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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