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TCMDC-135051

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Purity:98.21%

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COA HNMR HPLC

TCMDC-135051

Catalog No. T13102Cas No. 2413716-15-9

TCMDC-135051 is a potent and selective PfCLK3 protein kinase inhibitor demonstrating significant antiparasiticidal activity (EC50=320 nM) while exhibiting minimal off-target toxicity. It effectively hinders the transition from trophozoite to schizont, impairs transcription, and diminishes transmission to the mosquito vector.

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Pack Size	Price	Availability
1 mg	$79	In Stock
5 mg	$196	In Stock
10 mg	$337	In Stock
25 mg	$533	In Stock
50 mg	$693	In Stock
100 mg	$954	In Stock
500 mg	$1,930	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Product Introduction

Bioactivity

Description

In vitro

In a liver invasion and development assay, TCMDC-135051 shows potent activity against P. berghei sporozoites in which the compound shows a pEC50 value of 6.17 (EC50=0.40 μM). The kinase assays using recombinant PvCLK3 (P. vivax) and PbCLK3 (P. berghei) show that TCMDC-135051 has near-equipotent inhibition at these two orthologs, with pIC50 values of 7.47 (IC50=0.033 μM) and 7.86 (IC50=0.013 μM), respectively[1].

Chemical Properties

Molecular Weight	471.59
Formula	C29H33N3O3
Cas No.	2413716-15-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 225 mg/mL (477.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1205 mL	10.6024 mL	21.2049 mL	106.0243 mL
5 mM	0.4241 mL	2.1205 mL	4.2410 mL	21.2049 mL
10 mM	0.2120 mL	1.0602 mL	2.1205 mL	10.6024 mL
20 mM	0.1060 mL	0.5301 mL	1.0602 mL	5.3012 mL
50 mM	0.0424 mL	0.2120 mL	0.4241 mL	2.1205 mL
100 mM	0.0212 mL	0.1060 mL	0.2120 mL	1.0602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TCMDC-135051TCMDC135051TCMDC 135051