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TGFβ1-IN-1
🥰Excellent
Catalog No. T61389Cas No. 2348795-14-0
TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the study of cancer and autoimmune diseases.
TGFβ1-IN-1
🥰Excellent
Purity: 99.89%
Catalog No. T61389Cas No. 2348795-14-0
TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the study of cancer and autoimmune diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $92 | In Stock |
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Purity:99.89%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the study of cancer and autoimmune diseases. |
| In vitro | In HSCs (LX-2) cells, TGFβ1-IN-1 (20 μM; 24 or 72 hours) showed a survival rate of 77.5% and an inhibition rate of 30.3% for LX-2 cells. Additionally, it significantly inhibited the protein expression of fibronectin and α-SMA[1]. |
| In vivo | In the CCl4-induced liver fibrosis model of C57BL/6J mice, TGFβ1-IN-1 (15 or 30 mg/kg; oral administration; daily; 3 weeks) significantly prevented CCl4-induced liver injury and reduced liver weight factor, serum ALT, AST, CHO, and TG levels[1]. |
| Molecular Weight | 364.438 |
| Formula | C22H24N2O3 |
| Cas No. | 2348795-14-0 |
| Smiles | O=C(C=CC1=CC=C(OC)C=C1)NC2=CC=CC(=C2)C(=O)NC3CCCC3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (219.51 mM), Sonification is recommended. | |||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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