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Pentabromophenol

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COA LCMS

Pentabromophenol

Catalog No. T20319Cas No. 608-71-9

Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.

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Pack Size	Price	Availability	Quantity
1 g	$29	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Product Introduction

Bioactivity

Description	Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.
In vitro	Following 18hr exposure of murine BV-2 cells, at dose levels resulting in ≥80% viability (10 and 40 μM), limited alterations in pro-inflammatory responses were observed however, changes were observed in mitochondrial respiration. Basal respiration, ATP-linked respiration, maximum respiration, basal glycolytic and compensatory glycolysis were altered by Pentabromophenol. Phagocytosis was decreased for Pentabromophenol and TBBPA. NLRP3 inflammasome activation was assessed using BV-2-ASC (apoptosis-associated speck-like protein containing a CARD) reporter cells to visualize aggregate formation. Pentabromophenol, showed a direct stimulation of aggregate formation and properties as a NLRP3 inflammasome secondary trigger[1].
Alias	NSC 5717, NSC5717, NSC-5717

Chemical Properties

Molecular Weight	488.59
Formula	C6HBr5O
Cas No.	608-71-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 4.89 mg/mL (10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0467 mL	10.2335 mL	20.4671 mL	102.3353 mL
5 mM	0.4093 mL	2.0467 mL	4.0934 mL	20.4671 mL
10 mM	0.2047 mL	1.0234 mL	2.0467 mL	10.2335 mL

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