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Chebulinic acid

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Purity:98.91%

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COA HPLC HNMR

Chebulinic acid

Catalog No. TQ0184Cas No. 18942-26-2

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.

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Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$157	In Stock
10 mg	$230	In Stock
25 mg	$490	In Stock
50 mg	$728	In Stock
100 mg	$987	In Stock
500 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$280	In Stock

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Product Introduction

Bioactivity

Description	Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
Targets&IC50	H+, K+-ATPase:IC50 : 65.01 μg/ml
In vitro	Chebulinic acid obviously inhibited HQ/Cu(II)- and H(2)O(2)/Cu(II)-mediated pBR322 DNA strand breaks. When MRC-5 cells were treated with HQ/Cu(II), the presence of Chebulinic acid inhibited HQ/Cu(II)-mediated double-strand breaks of genomic DNA [1].
In vivo	Chebulinic acid had no effect on KCl-induced aortic contraction, but irreversibly inhibited the contractile responses to phenylephrine in an apparently non-competitive manner. Chebulinic acid also inhibited contractile responses of rat aorta to 5-hydroxytryptamine and angiotensin II. 3. Chebulinic acid inhibited the binding of [3H]-prazosin to dog aortic microsomal membranes in a concentration-dependent manner with an IC50 value of 0.34 mmol/L [2].

Chemical Properties

Molecular Weight	956.68
Formula	C41H32O27
Cas No.	18942-26-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 27.5 mg/mL (28.75 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0453 mL	5.2264 mL	10.4528 mL	52.2641 mL
5 mM	0.2091 mL	1.0453 mL	2.0906 mL	10.4528 mL
10 mM	0.1045 mL	0.5226 mL	1.0453 mL	5.2264 mL
20 mM	0.0523 mL	0.2613 mL	0.5226 mL	2.6132 mL

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