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TL02-59 dihydrochloride
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Catalog No. T13186LCas No. 2415263-06-6
TL02-59 dihydrochloride is an orally active inhibitor of the Src-family kinase Fgr, with an IC50 of 0.03 nM.
TL02-59 dihydrochloride
😃Good
Catalog No. T13186LCas No. 2415263-06-6
TL02-59 dihydrochloride is an orally active inhibitor of the Src-family kinase Fgr, with an IC50 of 0.03 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $773 | 35 days | |
| 50 mg | $3,240 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | TL02-59 dihydrochloride is an orally active inhibitor of the Src-family kinase Fgr, with an IC50 of 0.03 nM. |
| Targets&IC50 | FGR:0.03 nM , Hck:160 nM , Lyn:0.1 nM |
| In vitro | in TF-1 cells, TL02-59 dihydrochloride (0.1-1000 nM; 6 hours) potently inhibits Fgr autophosphorylation , with paritial inhibition at 0.1-1 nM and complete inhibition above 10 nM. Hck, Lyn and Flt3 are inhibited in the 100 to 1000 nM range. TL02-59 dihydrochloride induces growth arrest in primary AML bone marrow samples. TL02-59 dihydrochloride inhibits the growth and induced apoptosis of AML cell lines expressing this kinase with single-digit nM potency. |
| In vivo | TL02-59 (oral; 1 and 10 mg/kg; for three weeks) entirely eliminates AML cells from the spleen and peripheral blood in a mouse model of AML, while significantly suppressing bone marrow involvement. |
| Molecular Weight | 682.56 |
| Formula | C32H36Cl2F3N5O4 |
| Cas No. | 2415263-06-6 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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