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TL13-12
😃Good
Catalog No. T13930Cas No. 2229037-04-9
TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).
TL13-12
😃Good
Catalog No. T13930Cas No. 2229037-04-9
TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 1.016 € | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM). |
| Targets&IC50 | Cereblon:1.2 μM |
| In vitro | in H3122 cell and Karpas 299, TL13-12 (0-200 nM; 16 hours) is selective for degradation of ALK (DC50s of 10 nM and 180 nM, respectively). In Kelly and CHLA20 cells, TL13-12 (0-160 nM; 16 hours) degrades ALK and aurora A protein expression as a dose-dependent manner .TL13-12 (100 nM; 16 hours) significantly inhibits Tariqudan-induced ALK and Aurora A protein expression in CHLA20 cells. |
| Molecular Weight | 961.49 |
| Formula | C45H53ClN10O10S |
| Cas No. | 2229037-04-9 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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