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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $153 | In Stock | |
5 mg | $389 | In Stock | |
10 mg | $569 | In Stock | |
25 mg | $882 | In Stock | |
50 mg | $1,190 | In Stock | |
1 mL x 10 mM (in DMSO) | $348 | In Stock |
Description | Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells. |
In vitro | toddaculin displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells, suggesting it may serve as a pharmacological prototype for the development of novel anti-leukemic agents[1]. |
Molecular Weight | 274.31 |
Formula | C16H18O4 |
Cas No. | 4335-12-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/ml (200.51 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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