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Toddaculin

🥰Excellent
Catalog No. TN5888Cas No. 4335-12-0

Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.

Toddaculin

Toddaculin

🥰Excellent
Purity: 99.91%
Catalog No. TN5888Cas No. 4335-12-0
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.
Pack SizePriceAvailabilityQuantity
1 mg$40In Stock
5 mg$98In Stock
10 mg$163In Stock
25 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$94In Stock
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Purity:99.91%
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COA HPLC HNMR
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Product Introduction

Bioactivity
Description
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.
In vitro
toddaculin displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells, suggesting it may serve as a pharmacological prototype for the development of novel anti-leukemic agents[1].
Chemical Properties
Molecular Weight274.31
FormulaC16H18O4
Cas No.4335-12-0
SmilesCOc1cc2oc(=O)ccc2c(OC)c1CC=C(C)C
Relative Density.1.138 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/ml (200.51 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6455 mL18.2276 mL36.4551 mL182.2755 mL
5 mM0.7291 mL3.6455 mL7.2910 mL36.4551 mL
10 mM0.3646 mL1.8228 mL3.6455 mL18.2276 mL
20 mM0.1823 mL0.9114 mL1.8228 mL9.1138 mL
50 mM0.0729 mL0.3646 mL0.7291 mL3.6455 mL
100 mM0.0365 mL0.1823 mL0.3646 mL1.8228 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

inhibitosteoclastInhibitordifferentiationleukemicApoptosisosteoblastanti-inflammatoryToddaculincoumarin
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